Grabner M, Bachmann A, Rosenthal F, Striessnig J, Schultz C, Tautz D, Glossmann H
Institut für Biochemische Pharmakologie, Universität Innsbruck, Austria.
FEBS Lett. 1994 Feb 14;339(1-2):189-94. doi: 10.1016/0014-5793(94)80413-3.
The complete amino acid sequence of an invertebrate calcium channel alpha 1-subunit from housefly (Musca domestica) larvae (designated Mdl alpha 1) has been deduced by cDNA cloning and sequence analysis. Mdl alpha 1 shares higher percent sequence identity with 1,4-dihydropyridine (DHP)-sensitive L-type than with DHP-insensitive calcium channels. As shown by whole mount in situ hybridization and immunostaining Mdl alpha 1 is predominantly expressed in the larval body wall musculature.
通过cDNA克隆和序列分析，已推导出家蝇（Musca domestica）幼虫的一种无脊椎动物钙通道α1亚基（命名为Mdlα1）的完整氨基酸序列。与对二氢吡啶（DHP）不敏感的钙通道相比，Mdlα1与对DHP敏感的L型钙通道具有更高的序列同一性百分比。如整体原位杂交和免疫染色所示，Mdlα1主要在幼虫体壁肌肉组织中表达。
