Schlatmann T J, Becker A E
Am J Cardiol. 1977 Jan;39(1):13-20. doi: 10.1016/s0002-9149(77)80004-0.
The histologic changes that occur in the media of the normal aorta at various ages were studied in 100 normal aortas. These changes encompassed (1) cystic medial necrosis, defined as pooling of mucoid material; (2) elastin fragmentation, characterized by disruption of elastin lamellae; (3) fibrosis, defined as an increase in collagen at the expense of smooth muscle cells; and (4) medionecrosis, defined as areas with apparent loss of nuclei. The changes showed a striking correlation with age and may represent the normal aging process for the aorta as determined histologically. The alterations showed a close relation in onset and location within the media, suggesting a phenomenon if injury and repair caused by hemodynamic events. These findings in the normal aging aorta reveal that none of the histologic changes observed can be regarded as the specific structural alteration responsible for the development of dissecting aneurysm.
在100例正常主动脉中研究了不同年龄正常主动脉中膜发生的组织学变化。这些变化包括：（1）囊性中膜坏死，定义为黏液样物质积聚；（2）弹性蛋白断裂，其特征为弹性蛋白层破裂；（3）纤维化，定义为以平滑肌细胞为代价的胶原蛋白增加；（4）中膜坏死，定义为细胞核明显缺失的区域。这些变化与年龄显著相关，可能代表了通过组织学确定的主动脉正常老化过程。这些改变在中膜内的发生和位置上显示出密切关系，提示这是一种由血流动力学事件引起的损伤和修复现象。正常老化主动脉的这些发现表明，所观察到的组织学变化均不能被视为导致夹层动脉瘤形成的特定结构改变。
