Leung C Y, Ho F C, Srivastava G, Loke S L, Liu Y T, Chan A C
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
Histopathology. 1993 Nov;23(5):433-7. doi: 10.1111/j.1365-2559.1993.tb00491.x.
Classification of peripheral T-cell lymphomas based on morphological criteria can present problems due to overlap in histological features amongst the subtypes. An immunohistochemical study was designed to study the follicular dendritic cell patterns in 21 cases of peripheral T-cell lymphoma which had been classified using the updated Kiel classification. Three patterns of distribution were observed: 1 follicular dendritic cells not detected (3 cases); 2 follicular dendritic cells restricted to remnant follicle centres (7); 3 follicular dendritic cells present as an expanded network of cells exceeding the confines of germinal centres (11). Ten out of 11 angioimmunoblastic lymphomas showed an expanded network of follicular dendritic cells. The only negative case showed features which, on review, were in keeping with a pleomorphic, medium and large cell lymphoma showing an unusual proliferation of small venules. Other than angioimmunoblastic lymphomas, only one other case showed follicular dendritic cell hyperplasia. This was an unclassified peripheral T-cell lymphoma. We conclude that follicular dendritic cell hyperplasia may be used an an aid to diagnosis of the angioimmunoblastic type of peripheral T-cell lymphoma, and we recommend the routine staining of these cells in typing of T-cell lymphomas to facilitate comparison between centres.
基于形态学标准对外周T细胞淋巴瘤进行分类可能会出现问题，因为各亚型之间的组织学特征存在重叠。一项免疫组织化学研究旨在研究21例已使用更新的基尔分类法分类的外周T细胞淋巴瘤中的滤泡树突状细胞模式。观察到三种分布模式：1未检测到滤泡树突状细胞（3例）；2滤泡树突状细胞局限于残留的滤泡中心（7例）；3滤泡树突状细胞呈现为超出生发中心范围的细胞扩展网络（11例）。11例血管免疫母细胞性淋巴瘤中有10例显示滤泡树突状细胞扩展网络。唯一的阴性病例经复查显示的特征符合多形性中、大细胞淋巴瘤，伴有小静脉的异常增殖。除血管免疫母细胞性淋巴瘤外，只有另一例显示滤泡树突状细胞增生。这是一例未分类的外周T细胞淋巴瘤。我们得出结论，滤泡树突状细胞增生可用于辅助诊断血管免疫母细胞型外周T细胞淋巴瘤，并且我们建议在T细胞淋巴瘤分型中对这些细胞进行常规染色，以促进各中心之间的比较。
