Hachitanda Y, Tsuneyoshi M
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hum Pathol. 1994 Jan;25(1):67-72. doi: 10.1016/0046-8177(94)90173-2.
We studied the organoid pattern in neuroblastoma, defined here as a characteristic histologic feature of the thin fibrovascular meshwork regularly surrounding the individual nests of neuroblastic cells. Among 75 neuroblastomas in our files, 11 cases were qualified as having the recognizable organoid pattern by hematoxylin-eosin stain morphology. The patients comprised five girls and six boys with ages at diagnosis ranging from 1 to 60 months (mean age, 14 months). Nine of the tumors were adrenal and two were retroperitoneal primary. The stages were I (four cases), III (two cases), IV (two cases), and IVS (two cases). All eight patients younger than 1 year are alive and well, whereas two of three patients older than 1 year died of disease. Immunohistochemical staining of those tumors having an organoid pattern showed a considerable number of S-100 protein-positive spindle cells present, mainly in the meshwork areas. Putative Schwann cells were identified ultrastructurally in five of the six tumors examined. In conclusion, organoid pattern in neuroblastoma is easily recognizable, is an indicator of good prognosis in younger children, and may well represent a close relationship between neuroblasts and putative Schwann cells.
我们研究了神经母细胞瘤中的类器官模式，在此将其定义为一种特征性组织学特征，即薄的纤维血管网络有规律地围绕着单个神经母细胞巢。在我们存档的75例神经母细胞瘤中，有11例经苏木精-伊红染色形态学检查符合具有可识别的类器官模式。患者包括5名女孩和6名男孩，诊断时年龄从1个月至60个月不等（平均年龄14个月）。其中9例肿瘤起源于肾上腺，2例为腹膜后原发性肿瘤。分期为I期（4例）、III期（2例）、IV期（2例）和IVS期（2例）。所有8名1岁以下的患者均存活且情况良好，而3名1岁以上的患者中有2例死于该疾病。对那些具有类器官模式的肿瘤进行免疫组织化学染色显示，存在相当数量的S-100蛋白阳性梭形细胞，主要位于网络区域。在所检查的6例肿瘤中，有5例在超微结构上鉴定出了假定的施万细胞。总之，神经母细胞瘤中的类器官模式易于识别，是年幼儿童预后良好的一个指标，并且很可能代表神经母细胞与假定的施万细胞之间的密切关系。
