Putz A, Bogesits R, Müller W, Werner C
Frauenklinik, Bethesda Krankenhaus, Duisburg.
Infection. 1993;21 Suppl 1:S54-8. doi: 10.1007/BF01710345.
At the Gynaecology Department of the Bethesda Hospital, 100 patients undergoing a laparoscopic appendectomy were recruited for a prospective study. The first ten patients received no antibiotic, the second ten were given a three-day course of cephazolin, the third ten were treated with a combination of sulbactam and ampicillin and the remaining 70 received cefuroxime. There were no significant differences between the four groups in the mean operating time, the intraoperative complication rate or in the degree of inflammation as classified by the histological examination. The reduced rate of postoperative complications defined as pyrexia > 38 degrees C, elevated WBC and peritoneal irritation for more than two days, showed the advantage of antibiotic prophylaxis with cefuroxime with respect to single parameters and overall complication rates. There were no intraoperative or severe postoperative complications.
在贝塞斯达医院妇科，100例行腹腔镜阑尾切除术的患者被纳入一项前瞻性研究。前10名患者未接受抗生素治疗，接下来的10名患者接受了为期三天的头孢唑林治疗，再接下来的10名患者接受了舒巴坦和氨苄西林联合治疗，其余70名患者接受了头孢呋辛治疗。四组患者在平均手术时间、术中并发症发生率或组织学检查分类的炎症程度方面无显著差异。术后并发症发生率降低，定义为发热>38摄氏度、白细胞升高和腹膜刺激超过两天，这显示了头孢呋辛预防性使用抗生素在单一参数和总体并发症发生率方面的优势。没有术中或严重术后并发症。
