干扰素α-2b治疗慢性丙型肝炎的临床及组织学评估
Clinical and histological evaluation of interferon alfa-2b in the treatment of chronic hepatitis C.
作者信息
Panella C, Francavilla A, Conte D, Tatulli I, Rubini F
机构信息
Department of Gastroenterology, University of Bari, Italy.
出版信息
Gut. 1993;34(2 Suppl):S127. doi: 10.1136/gut.34.2_suppl.s127.
In a study of 37 patients with hepatitis C (proved histologically) positive chronic hepatitis, a correlation was seen between clinical efficacy and histological improvement after treatment with interferon alfa-2b (3 million units (MU) three times a week for six months plus six months' follow up). Alanine aminotransferase activities became normal in 18 (48%) patients during treatment; at the end of follow up eight (45%) had a continued response to the treatment. Paired liver biopsy specimens showed marked improvements in Knodell index score and portal inflammation in these patients.
在一项对37例经组织学证实为丙型肝炎阳性的慢性肝炎患者的研究中，观察到用α-2b干扰素治疗（每周3次，每次300万单位，持续6个月并随访6个月）后临床疗效与组织学改善之间的相关性。18例（48%）患者在治疗期间丙氨酸转氨酶活性恢复正常；随访结束时，8例（45%）患者对治疗持续有反应。配对的肝活检标本显示这些患者的Knodell指数评分和门静脉炎症有明显改善。
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