用重组干扰素α-2b治疗慢性丙型肝炎。
Treatment of chronic hepatitis C with recombinant interferon alfa-2b.
作者信息
Piazza M, Orlando R, Tosone G, Tiseo D, Conte M C, Minervini F, Santoro G, Scordino F, Vitale D
机构信息
Department of Infectious Diseases, II Medical School, University of Naples, Italy.
出版信息
Gut. 1993;34(2 Suppl):S128-9. doi: 10.1136/gut.34.2_suppl.s128.
In a study of 87 patients with chronic hepatitis C, 12 months' treatment with interferon alfa-2b at a dose of 6 million units (MU) three times per week seemed to be more effective than treatment with 3 MU three times a week for two months plus 1.5 MU three times a week for 10 months in increasing the percentage of long term responders. The percentage of patients in whom alanine amino-transferase activities returned to normal was highest in the 6 MU group, as was the percentage of responders who sustained this normal activity after treatment. Side effects were moderate and self-limited in most patients.
在一项针对87例慢性丙型肝炎患者的研究中，每周三次给予600万单位（MU）的干扰素α-2b治疗12个月，在提高长期缓解者比例方面似乎比每周三次给予3MU治疗两个月加每周三次给予1.5MU治疗10个月更有效。丙氨酸转氨酶活性恢复正常的患者比例在6MU组中最高，治疗后维持这种正常活性的缓解者比例也是如此。大多数患者的副作用为中度且具有自限性。
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