Pérez R, Pravia R, Linares A, Rodríguez M, Lombraña J L, Suárez A, Riestra S, Navascués C A, Rodrigo L
Gastroenterology Unit, Hospital Central de Asturias, School of Medicine, Oviedo, Spain.
Gut. 1993;34(2 Suppl):S139-40. doi: 10.1136/gut.34.2_suppl.s139.
In an analysis of the clinical and laboratory variables that can influence the response to interferon alfa-2b treatment, 48 patients with chronic hepatitis C virus infection received interferon 5 million units (MU) subcutaneously three times weekly for eight weeks followed by 3 MU three times weekly for seven months. Response related factors on univariate analysis were found to be age > 40 years, non-parenteral source of infection, pretreatment positive antinuclear antibodies (ANA), cirrhosis, and high serum iron, ferritin, gamma glutamyl transferase, and IgM. An independent predictive value (multivariate analysis) was also found for cirrhosis, ANA, serum iron, and ferritin. A baseline aspartate aminotransferase/alanine aminotransferase ratio of 0.5 and a striking increase during interferon treatment were associated with a complete response.
在一项对可能影响干扰素α-2b治疗反应的临床和实验室变量的分析中，48例慢性丙型肝炎病毒感染患者接受皮下注射干扰素500万单位（MU），每周3次，共8周，随后每周3次，每次3MU，持续7个月。单因素分析发现与反应相关的因素为年龄>40岁、非肠道外感染源、治疗前抗核抗体（ANA）阳性、肝硬化以及血清铁、铁蛋白、γ-谷氨酰转移酶和IgM水平升高。在多因素分析中还发现肝硬化、ANA、血清铁和铁蛋白具有独立的预测价值。基线天冬氨酸氨基转移酶/丙氨酸氨基转移酶比值为0.5以及干扰素治疗期间显著升高与完全缓解相关。
