Di Marco V, Lo Iacono O, Capra M, Grutta S, Ciaccio C, Gerardi C, Maggio A, Renda D, Almasio P, Pisa R
Clinica Medica R and Anat Patologica, Ospedale Cervello, Palermo, Sicily, Italy.
Gut. 1993;34(2 Suppl):S142-3. doi: 10.1136/gut.34.2_suppl.s142.
In this open, pilot study, interferon (IFN) alpha-2b seemed effective in the treatment of hepatitis C virus (HCV) infection in patients with beta-thalassaemia. In seven of nine patients who completed the study alanine aminotransferase activities returned to normal, and a completely stable response 24 months after treatment was seen in five. Liver biopsy specimen showed a clear reduction in portal, periportal, and lobular necroinflammation in all five cases. Three patients stopped treatment early because of side effects.
在这项开放性的试点研究中，α-2b干扰素似乎对治疗β地中海贫血患者的丙型肝炎病毒（HCV）感染有效。在完成研究的9名患者中，有7名患者的丙氨酸转氨酶活性恢复正常，5名患者在治疗后24个月出现了完全稳定的反应。肝活检标本显示，所有5例患者的门静脉、门静脉周围和小叶坏死性炎症均明显减轻。3名患者因副作用提前停止了治疗。
