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白细胞黏附抑制试验(LAI)在上皮性卵巢癌术前诊断中的应用

The leukocyte adherence inhibition test (LAI) in preoperative diagnosis of epithelial ovarian cancer.

作者信息

Dgani R, Shani A, Elchalal U, Harpaz N, Bentwich Z, Fink A

机构信息

Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.

出版信息

Gynecol Oncol. 1993 Jun;49(3):349-53. doi: 10.1006/gyno.1993.1138.

DOI:10.1006/gyno.1993.1138
PMID:8314537
Abstract

One hundred two women admitted for evaluation of an adnexal mass were tested prior to surgery by the computerized tube leukocyte adherence inhibition (LAI) assay. The test was positive in 24/35 (69%) patients, diagnosed after surgery as epithelial ovarian cancer while 50/67 (75%) of those diagnosed as benign masses were negative. Only 2/38 (5%) of normal control subjects showed a false-positive result. The LAI test described in this report showed a sensitivity of 88% and a specificity of 75% in stage I ovarian cancer; thus it may be useful for early diagnosis of ovarian malignancy.

摘要

102名因附件包块入院接受评估的女性在手术前通过计算机化的输卵管白细胞黏附抑制(LAI)试验进行了检测。在术后被诊断为上皮性卵巢癌的35名患者中,该试验有24名(69%)呈阳性,而在被诊断为良性包块的67名患者中,有50名(75%)呈阴性。正常对照受试者中只有2/38(5%)出现假阳性结果。本报告中描述的LAI试验在I期卵巢癌中的敏感性为88%,特异性为75%;因此,它可能有助于卵巢恶性肿瘤的早期诊断。

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