细胞因子受体基因家族的一个新成员定位于21号染色体上，距离干扰素α/β受体（IFNAR）不到35千碱基对处。
A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.
作者信息
Lutfalla G, Gardiner K, Uzé G
机构信息
Laboratory of Viral Oncology, IRSC, CNRS, Villejuif, France.
出版信息
Genomics. 1993 May;16(2):366-73. doi: 10.1006/geno.1993.1199.
A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb.
克隆了一个与定位于D21S58位点的基因相对应的全长cDNA。所编码的蛋白质称为CRF2-4，被证明是细胞因子受体家族的典型II类成员。编码CRF2-4的基因跨度超过30 kb。确定了其内含子/外显子结构，并显示与细胞因子受体家族的所有其他成员保守。CRF2-4基因与其IFNAR邻居之间的物理距离已缩小至小于35 kb。
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