Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA,
Curr Top Microbiol Immunol. 2014;380:191-212. doi: 10.1007/978-3-662-43492-5_9.
Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.
细胞表面 IL-10 受体复合物的组装是启动 IL-10 信号通路的第一步，该信号通路可调节肠道炎症、病毒持续存在，甚至肿瘤监视。疱疹病毒基因组中发现的 IL-10 同源物表明，IL-10 信号通路可以在受体复合物水平上进行操作。本章将根据细胞和病毒 IL-10 受体复合物的晶体结构和生化分析，描述我们目前对 IL-10 受体组装的分子认识。
