丙吡胺对左心室功能的影响：药物及其单-N-脱烷基代谢物的游离浓度和总浓度与无创功能指标的关系。

Effect of disopyramide on left ventricular performance: the relationship of free and total concentrations of the drug and of its mono-N-dealkylated metabolite to noninvasive indices of function.

作者信息

Holt G W, Norris R L, Ravenscroft P J, Bett J H, Dryburgh L G, Boyle C M

出版信息

J Cardiovasc Pharmacol. 1983 Jan-Feb;5(1):51-4.

Abstract

We used M-mode echocardiography and recordings of systolic time intervals to follow changes in left ventricular systolic function of 10 normal subjects during administration of 200 mg oral disopyramide every 8 h. Left ventricular function was significantly depressed (peak rate of change of dimension - 17%, p less than 0.001; mean velocity of circumferential fiber shortening - 15%, p less than 0.01; percent fractional shortening - 16%, p less than 0.05) for as long as 7 h after a dose. These changes could be correlated with those in plasma concentrations of free and total disopyramide, and of its mono-N-dealkylated metabolite (change in peak rate of change of dimension versus levels of disopyramide plus metabolite, r = -0.41, p less than 0.03; changes in ratio preejection time/ejection time versus levels of disopyramide and metabolite, r = 0.62, p less than 0.002).

摘要

我们采用M型超声心动图和收缩期时间间期记录法，对10名正常受试者每8小时口服200毫克双异丙吡胺期间左心室收缩功能的变化进行了跟踪研究。给药后长达7小时，左心室功能显著降低（内径变化峰值速率降低17%，p<0.001；圆周纤维缩短平均速度降低15%，p<0.01；缩短分数百分比降低16%，p<0.05）。这些变化与游离和总双异丙吡胺及其单-N-去烷基代谢产物的血浆浓度变化相关（内径变化峰值速率变化与双异丙吡胺加代谢产物水平的关系，r = -0.41，p<0.03；射血前期时间/射血时间比值变化与双异丙吡胺和代谢产物水平的关系，r = 0.62，p<0.002）。