Jansen J A, van der Waerden J P, Wolke J G
Department of Oral Function and Prosthetic Dentistry, Dental School, University of Nijmegen, The Netherlands.
J Biomed Mater Res. 1993 May;27(5):603-10. doi: 10.1002/jbm.820270507.
The aim of this study was to investigate bone response to and biostability of three different hydroxyapatite (HA)-coatings. Therefore, coated and uncoated titanium implants were inserted into the tibia of rabbits. Implantation times were at 3 and 12 weeks. The histological evaluation included measurement of the amount of bone apposition to the various implant surfaces. The results demonstrated at 3 and 12 weeks no marked differences in bony reaction at the cortical level to the different implant materials. However, compared with the 3-week specimens, at 12 weeks extensive maturation of the woven bone callus had occurred. In addition, all 12-week implants induced bone formation in the medullary cavity. It was also noted that all HA-coatings showed loss of coating thickness. Quantitative determination of bone contact demonstrated that all 12-week implants showed the same high amount of bone apposition.
本研究的目的是调查三种不同羟基磷灰石（HA）涂层的骨反应及生物稳定性。因此，将涂层和未涂层的钛植入物植入兔胫骨。植入时间为3周和12周。组织学评估包括测量不同植入物表面的骨附着量。结果表明，在3周和12周时，皮质水平对不同植入材料的骨反应无明显差异。然而，与3周的标本相比，12周时编织骨痂广泛成熟。此外，所有12周的植入物均在髓腔内诱导骨形成。还注意到所有HA涂层的涂层厚度均有损失。骨接触的定量测定表明，所有12周的植入物均显示出相同的高骨附着量。
