Vasicka A, Kumaresan P, Li C, Scheffs J
Am J Obstet Gynecol. 1977 Jan 15;127(2):171-5. doi: 10.1016/s0002-9378(16)33245-8.
Immunologic and biologic activity of oxytocin (OT) were studied by simultaneous monitoring of plasma OT measured by radioimmunoassay (RIA) and uterine contractility measured by recording of intrauterine pressures during the step-up rate of infusion of synthetic OT. The results in 11 patients with midtrimester pregnancy and step-up increase of OT infusion by 20 mU. showed a positive correlation of the increase of plasma OT and uterine contractility only at the plasma OT levels of 20 to 60 muU. per milliliter and only with hypertonic contractility but no correlation at plasma levels below and above this range. The lack of correlation of "dose and response" either prior to OT infusion or during low or very high rate of infusion suggests that other factors than merely the quantity of plasma OT are involved in determining the degree of uterine response.
通过在递增输注合成催产素（OT）过程中，同时监测采用放射免疫测定法（RIA）测得的血浆OT和记录子宫内压力测得的子宫收缩力，研究了催产素（OT）的免疫和生物学活性。11例中期妊娠患者在OT输注以20 mU递增时的结果显示，仅在血浆OT水平为每毫升20至60 μU时，血浆OT升高与子宫收缩力呈正相关，且仅与高张性收缩相关，在此范围以下和以上的血浆水平时无相关性。在OT输注前或低输注率或高输注率期间缺乏“剂量与反应”的相关性，这表明除了血浆OT的量之外，其他因素也参与了子宫反应程度的决定。
