Seitchik J, Amico J, Robinson A G, Castillo M
Am J Obstet Gynecol. 1984 Oct 1;150(3):225-8. doi: 10.1016/s0002-9378(84)90355-7.
Plasma oxytocin levels ([OT[p) were measured every 20 minutes during infusions of oxytocin. The initial dose of 1 mU/min was incremented, if necessary, by 1 mU/min at 40-minute intervals until sufficient contractility was obtained to effect cervical dilatation. The results demonstrated: the [OT]p rises linearly with each dose for the first 40 minutes of the infusion; there is no difference between the 40- and 60-minute sample values, suggesting that the peak [OT]p of each dose is achieved in 40 minutes; the increment in [OT]p required to produce effective contractility varies widely from 0.58 to 5.09 microU/ml; the plasma clearance rate varied from 11.2 to 32.5 ml/kg/min. Approximately 40 minutes is required for any particular dose of oxytocin to reach a "steady-state" [OT]p and the maximal uterine contractile response. The design of regimens for the augmentation or induction of labor should be based on this knowledge.
在输注催产素期间，每隔20分钟测量一次血浆催产素水平（[OT]p）。初始剂量为1 mU/分钟，如有必要，每隔40分钟以1 mU/分钟的幅度递增，直至获得足够的宫缩力以实现宫颈扩张。结果表明：在输注的前40分钟内，[OT]p随每次剂量呈线性上升；40分钟和60分钟的样本值之间没有差异，这表明每个剂量的[OT]p峰值在40分钟内达到；产生有效宫缩力所需的[OT]p增量差异很大，从0.58到5.09微单位/毫升不等；血浆清除率在11.2至32.5毫升/千克/分钟之间变化。任何特定剂量的催产素达到“稳态”[OT]p和最大子宫收缩反应大约需要40分钟。引产或催产方案的设计应基于这一认识。
