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Experimental bleomycin lung in mice. A contribution to the pathogenesis of pulmonary fibrosis.

作者信息

Fasske E, Morgenroth K

出版信息

Lung. 1983;161(3):133-46. doi: 10.1007/BF02713855.

DOI:10.1007/BF02713855
PMID:6192292
Abstract
摘要

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1
Experimental bleomycin lung in mice. A contribution to the pathogenesis of pulmonary fibrosis.小鼠博来霉素诱导的实验性肺损伤。对肺纤维化发病机制的研究
Lung. 1983;161(3):133-46. doi: 10.1007/BF02713855.
2
[Surfactant-inducted suppressive action on fibroblasts of pulmonary macrophages from rats with fibrosis after intratracheal administration of bleomycin].[博来霉素气管内给药后肺纤维化大鼠肺巨噬细胞对成纤维细胞的表面活性剂诱导抑制作用]
Probl Tuberk. 1991(12):46-9.
3
[Kinetics and mechanism in bleomycin-induced murine pulmonary fibrosis model].[博来霉素诱导的小鼠肺纤维化模型中的动力学与机制]
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Aug;18(8):474-8.
4
Bleomycin induces strain-dependent alterations in the pattern of epithelial cell-specific marker expression in mouse lung.博来霉素可诱导小鼠肺上皮细胞特异性标志物表达模式的应变依赖性改变。
Toxicol Appl Pharmacol. 1997 Feb;142(2):303-10. doi: 10.1006/taap.1996.8056.
5
[The morphofunctional changes in the alveolar epithelium, macrophages and pulmonary surfactant of rats with bleomycin-induced fibrosis].[博来霉素诱导的大鼠肺纤维化中肺泡上皮、巨噬细胞和肺表面活性物质的形态功能变化]
Morfologiia. 1993 Mar-Apr;104(3-4):119-31.
6
[Experimentally induced bleomycin pulmonary toxicity--comparison of the systemic (intraperitoneal) and local (intratracheal) administration].[实验性诱导博来霉素肺毒性——全身（腹腔内）给药与局部（气管内）给药的比较]
Gan To Kagaku Ryoho. 1983 Dec;10(12):2550-7.
7
Changes in pulmonary surfactant function and composition in bleomycin-induced pneumonitis and fibrosis.博来霉素诱导的肺炎和肺纤维化中肺表面活性物质功能及成分的变化
Toxicol Appl Pharmacol. 2004 Mar 1;195(2):218-31. doi: 10.1016/j.taap.2003.11.011.
8
Phosphoinositide 3-kinase γ plays a critical role in bleomycin-induced pulmonary inflammation and fibrosis in mice.磷酸肌醇 3-激酶 γ 在博来霉素诱导的小鼠肺炎症和纤维化中发挥关键作用。
J Leukoc Biol. 2011 Feb;89(2):269-82. doi: 10.1189/jlb.0610346. Epub 2010 Nov 2.
9
Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin.巨噬细胞中MMP9的过表达可减轻博来霉素诱导的肺纤维化。
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Mouse models of bleomycin-induced pulmonary fibrosis.博来霉素诱导的肺纤维化小鼠模型。
Curr Protoc Pharmacol. 2008 Mar;Chapter 5:Unit 5.46. doi: 10.1002/0471141755.ph0546s40.

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Lung surfactant as a biophysical assay for inhalation toxicology.肺表面活性剂作为吸入毒理学的生物物理检测方法。
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本文引用的文献

1
Clinical, radiologic, and histopathologic studies on pulmonary toxicity induced by treatment with bleomycin (NSC-125066).博来霉素（NSC-125066）治疗所致肺毒性的临床、放射学及组织病理学研究
Cancer Chemother Rep. 1972 Jun;56(3):343-56.
2
Interstitial pulmonary fibrosis following busulfan therapy.白消安治疗后发生的间质性肺纤维化。
Am J Med. 1961 Jul;31:134-9. doi: 10.1016/0002-9343(61)90229-7.
3
A new antibiotic, phleomycin.一种新的抗生素，博来霉素。
活性氧诱导的内皮应激通过周细胞和Wnt信号通路导致肺纤维化。
Lab Invest. 2016 Feb;96(2):206-17. doi: 10.1038/labinvest.2015.100. Epub 2015 Sep 14.
4
Comprehensive lung injury pathology induced by mTOR inhibitors.mTOR 抑制剂引起的全面性肺损伤病理学。
Clin Transl Oncol. 2009 Aug;11(8):499-510. doi: 10.1007/s12094-009-0394-y.
5
Extracellular superoxide dismutase in pulmonary fibrosis.肺纤维化中的细胞外超氧化物歧化酶
Antioxid Redox Signal. 2008 Feb;10(2):343-54. doi: 10.1089/ars.2007.1908.
6
Phospholipid analysis of alveolar macrophages and bronchoalveolar lavage fluid following bleomycin administration to rabbits.博来霉素给药后兔肺泡巨噬细胞和支气管肺泡灌洗液的磷脂分析
Lung. 1994;172(2):91-102. doi: 10.1007/BF00185080.
7
Pathogenesis of pulmonary fibrosis induced by chrysotile asbestos. Longitudinal light and electron microscopic studies on the rat model.温石棉所致肺纤维化的发病机制。大鼠模型的纵向光镜和电镜研究。
Virchows Arch A Pathol Anat Histopathol. 1986;408(4):329-46. doi: 10.1007/BF00707692.
8
In vivo studies of rat alveolar macrophage [corrected] microviscosity: influence of pulmonary surfactant synthesis stimulation.大鼠肺泡巨噬细胞[校正后]微粘度的体内研究：肺表面活性物质合成刺激的影响。
Lung. 1987;165(6):333-40. doi: 10.1007/BF02714449.
9
Pulmonary toxicity of the combination of bleomycin and peplomycin--an experimental study in rats.博来霉素与培普利欧霉素联合应用的肺毒性——大鼠实验研究
Cancer Chemother Pharmacol. 1991;28(5):357-60. doi: 10.1007/BF00685689.
10
The effect of bleomycin on the uptake and incorporation of [14C]choline into phospholipids in hamster lung tissue slices.博来霉素对仓鼠肺组织切片中[14C]胆碱摄取及掺入磷脂的影响。
Lipids. 1990 Dec;25(12):863-6. doi: 10.1007/BF02535911.
J Antibiot (Tokyo). 1956 Mar;9(2):82-5.
4
The morphology, kinetics and fate of granulomas.
Verh Dtsch Ges Pathol. 1980;64:21-4.
5
[Chemokinesis, chemotaxis and functions of phagocytes, with special reference to macrophages (author's transl)].趋化作用、趋化性及吞噬细胞的功能，特别提及巨噬细胞（作者译）
Verh Dtsch Ges Pathol. 1980;64:24-47.
6
Isolated type II cells from fetal lung as model in studies on the synthesis and secretion of pulmonary surfactant.从胎肺中分离出的II型细胞作为肺表面活性物质合成与分泌研究的模型。
Lung. 1980;158(4):177-92. doi: 10.1007/BF02713722.
7
Bleomycin-induced pulmonary fibrosis in rats: biochemical demonstration of increased rate of collagen synthesis.博来霉素诱导的大鼠肺纤维化：胶原蛋白合成速率增加的生化证明
Am Rev Respir Dis. 1980 Mar;121(3):501-6. doi: 10.1164/arrd.1980.121.3.501.
8
Biochemical and morphological assessments of bleomycin pulmonary toxicity in rats.大鼠博来霉素肺毒性的生化和形态学评估。
Toxicol Appl Pharmacol. 1980 Mar 30;53(1):64-74. doi: 10.1016/0041-008x(80)90382-8.
9
Lung damage from cytotoxic drugs.细胞毒性药物所致的肺损伤。
Cancer Chemother Pharmacol. 1980;4(1):17-27. doi: 10.1007/BF00255453.
10
Activity and toxicity of bleomycin.博来霉素的活性与毒性
J Antibiot (Tokyo). 1967 Jan;20(1):15-24.