Malczak H T, Buck R C
Am J Pathol. 1977 Jan;86(1):133-48.
Immediately after freezing the abdominal aorta of rats by applying a cold probe, the endothelium is desquamated or necrotic and platelets adhere to desquamated areas (at the earliest observable time) but not to necrotic endothelium or endothelium adjacent to the injury. Preferential adhesion of platelets to fenestrations of the internal elastic laimina appears to lead to their active migration into the media, where a large number may be present up to 8 days after injury. Platelets seems to be removed from the surface by the action of the advancing edge of the regenerating endothelium, moving at a maximum mean rate of 590 mu daily. An increase in area of individual cells appears to relate better than an increase in their number to the advance of the edge of the regenerating sheet.
通过应用冷探针冷冻大鼠腹主动脉后，内皮立即脱落或坏死，血小板在最早可观察到的时间粘附于脱落区域，但不粘附于坏死内皮或损伤附近的内皮。血小板优先粘附于内弹性膜的窗孔似乎导致它们活跃迁移到中膜，在损伤后长达8天可能有大量血小板存在。血小板似乎通过再生内皮前沿的作用从表面被清除，其最大平均移动速度为每天590微米。单个细胞面积的增加似乎比其数量的增加与再生片边缘的推进关系更密切。
