Kurita A, Blass J P, Nolan K A, Black R S, Thaler H T
Dementia Research Service, Cornell University Medical College, Burke Medical Research Institute, White Plains, New York 10605.
J Am Geriatr Soc. 1993 Jul;41(7):732-6. doi: 10.1111/j.1532-5415.1993.tb07462.x.
To investigate the relationship between cognitive and behavioral impairments in Alzheimer's disease (AD) and to examine whether the addition of cerebrovascular disease modifies that relationship.
Correlational analysis.
An outpatient dementia clinic.
An autopsy-confirmed series of 28 patients with AD and 16 patients with mixed Alzheimer and vascular dementia (MIX).
Neuropsychological and behavioral tests during life: Mini-Mental State (MMS), Blessed Dementia Scale (BDS), Haycox Dementia Behavior Scale (HDBS), and two non-cognitive functional scales derived from the BDS and HDBS.
In the AD group, MMS scores correlated significantly with scores on the BDS, HDBS, and two non-cognitive functional scales. In the MIX group, however, no significant relationship was observed between MMS scores and scores on any of the behavioral measures.
These observations suggest that in AD, cognitive and behavioral impairments progress simultaneously. However, with the addition of a vascular component to the dementing process, cognitive and behavioral impairments may progress more independently.
研究阿尔茨海默病（AD）患者认知和行为障碍之间的关系，并探讨脑血管疾病的合并存在是否会改变这种关系。
相关性分析。
门诊痴呆诊所。
经尸检确诊的28例AD患者和16例阿尔茨海默病合并血管性痴呆（MIX）患者。
生前进行神经心理学和行为测试：简易精神状态检查表（MMS）、Blessed痴呆量表（BDS）、Haycox痴呆行为量表（HDBS），以及从BDS和HDBS衍生出的两个非认知功能量表。
在AD组中，MMS评分与BDS、HDBS及两个非认知功能量表的评分显著相关。然而，在MIX组中，未观察到MMS评分与任何行为测量指标的评分之间存在显著关系。
这些观察结果表明，在AD中，认知和行为障碍同时进展。然而，在痴呆过程中加入血管成分后，认知和行为障碍可能会更独立地进展。
