Dong YanHong, Gan Daniel Zheng Qiang, Tay Stephen Ziyang, Koay Way Inn, Collinson Simon Lowes, Hilal Saima, Venketasubramanian Narayanaswamy, Chen Christopher
Memory Aging and Cognition Centre, Department of Pharmacology, National University Health System, Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Centre for Healthy Brain Ageing and Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, The University of New South Wales, Australia.
J Neurol Sci. 2013 Oct 15;333(1-2):5-8. doi: 10.1016/j.jns.2013.05.011. Epub 2013 Jul 25.
Mixed dementia (MD), i.e., the coexistence of Alzheimer's disease (AD) and cerebrovascular disease (CVD), is a common dementia subtype. Few studies have attempted to establish the cognitive profiles of mild-moderate MD and compare it to the profiles of AD using a comprehensive neuropsychological test battery. We aimed to establish the neuropsychological profile of mild-moderate MD in relation to mild-moderate AD.
Patients with consensus diagnoses of MD and AD of mild-moderate severity (Clinical Dementia Rating score of 1-2) were recruited from a memory clinic. Cognitive performance was measured by a formal neuropsychological battery covering domains of attention, language, verbal and visual memory, visuoconstruction, visuomotor speed and executive function. Cognitive domain scores are z-scores calculated using the mean and SDs of the AD group. ANCOVAs with age and education as covariates were employed to examine differences in mean score difference of cognitive domains and subtests between patients with MD and AD.
151 patients were recruited with the majority of AD (n=96, 63.6%) and a minority of MD (n=55, 36.4%). There were no significant differences in the demographic characteristics of patients with MD and AD. However, patients with MD were significantly more impaired than AD patients in global cognitive composite, attention and visuoconstruction (global cognitive composite: -0.32±0.98 vs 0±1, p=0.011; attention: -0.32±0.90 vs 0±1, p=0.013; visuoconstruction: -0.27±0.99 vs 0±1, p=0.024, respectively).
The neuropsychological profile of patients with MD of mild-moderate severity is characterized by a poorer global performance, as well as attention and visuoconstruction than those with AD of mild-moderate severity.
混合性痴呆（MD），即阿尔茨海默病（AD）与脑血管病（CVD）共存，是一种常见的痴呆亚型。很少有研究尝试使用全面的神经心理测试组合来确立轻 - 中度MD的认知特征，并将其与AD的特征进行比较。我们旨在确立轻 - 中度MD相对于轻 - 中度AD的神经心理特征。
从记忆门诊招募了轻 - 中度严重程度（临床痴呆评定量表评分为1 - 2）的MD和AD共识诊断患者。通过涵盖注意力、语言、言语和视觉记忆、视觉构建、视觉运动速度和执行功能等领域的正式神经心理测试组合来测量认知表现。认知领域得分是使用AD组的均值和标准差计算得出的z分数。采用年龄和教育程度作为协变量的协方差分析来检验MD和AD患者在认知领域和子测试平均得分差异方面的差异。
共招募了151名患者，其中大多数为AD患者（n = 96，63.6%），少数为MD患者（n = 55，36.4%）。MD和AD患者的人口统计学特征无显著差异。然而，MD患者在整体认知综合、注意力和视觉构建方面的受损程度明显高于AD患者（整体认知综合：-0.32±0.98 vs 0±1，p = 0.011；注意力：-0.32±0.90 vs 0±1，p = 0.013；视觉构建：-0.27±0.99 vs 0±1，p = 0.024）。
轻 - 中度严重程度的MD患者的神经心理特征表现为整体表现较差，以及在注意力和视觉构建方面比轻 - 中度严重程度的AD患者差。
