大鼠胆总管-输尿管吻合术。一种长期、完全、内引流胆汁的新实验模型。

Choledocho-ureteral anastomosis in the rat. A new experimental model of long-term, total, internal bile diversion.

作者信息

Audry G, Giral P, Bonnefis M T, Legendre C, Myara A, Poupon R

机构信息

Equipe de Physiologie et Pharmacologie Hépatique, INSERM U-181, CHU Saint-Antoine, Paris, France.

出版信息

J Hepatol. 1993 Mar;17(3):373-6. doi: 10.1016/s0168-8278(05)80220-x.

DOI:10.1016/s0168-8278(05)80220-x

PMID:8315265

Abstract

Choledocho-ureteral anastomosis is a new experimental model of total bile diversion in the rat. The anastomosis is carried out using a polyethylene tutor drain and requires neither an external drain nor restraint of the animal. After 14 days of diversion, bile flow fell by 53% and there were no biological signs of cholestasis. The rats survived for up to 2 months. Choledocho-ureteral anastomosis is a reliable and simple experimental model which can be used to study the effects of prolonged interruption of enterohepatic bile-acid circulation.

摘要

胆总管-输尿管吻合术是一种新的大鼠全胆汁引流实验模型。吻合术采用聚乙烯支撑引流管进行，既不需要外部引流，也不需要限制动物活动。引流14天后，胆汁流量下降了53%，且没有胆汁淤积的生物学迹象。大鼠存活长达2个月。胆总管-输尿管吻合术是一种可靠且简单的实验模型，可用于研究肠肝胆汁酸循环长期中断的影响。