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Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.用由抗体可变区和Fc受体γ链组成的嵌合基因重定向的人淋巴细胞对卵巢癌细胞进行裂解。
J Exp Med. 1993 Jul 1;178(1):361-6. doi: 10.1084/jem.178.1.361.
2
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3
Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma.单链抗癌胚抗原抗体在细胞毒性T淋巴细胞中的表达。Fas配体介导的结肠癌重定向裂解。
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4
T cell receptor V beta 2 and V beta 6 mediate tumor-specific cytotoxicity by tumor-infiltrating lymphocytes in ovarian cancer.T细胞受体Vβ2和Vβ6介导卵巢癌中肿瘤浸润淋巴细胞的肿瘤特异性细胞毒性。
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8
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Clin Cancer Res. 1996 Jan;2(1):87-95.

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本文引用的文献

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Functional and molecular characterization of tumor-infiltrating lymphocytes transduced with tumor necrosis factor-alpha cDNA for the gene therapy of cancer in humans.用肿瘤坏死因子-α cDNA 转导的肿瘤浸润淋巴细胞用于人类癌症基因治疗的功能和分子特征分析
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Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.通过由抗体结合域以及免疫球蛋白和T细胞受体的γ或ζ亚基组成的嵌合单链对细胞毒性淋巴细胞进行特异性激活和靶向。
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Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice.人卵巢腺癌细胞系IGROV1在组织培养和裸鼠中的特性研究。
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Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production.逆转录病毒包装细胞系的重新设计，以避免重组导致辅助病毒产生。
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Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody.与抗靶细胞抗体相连的抗T3对细胞毒性T细胞的特异性靶向作用。
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Single-chain antigen-binding proteins.单链抗原结合蛋白
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Expression of chimeric receptor composed of immunoglobulin-derived V regions and T-cell receptor-derived C regions.由免疫球蛋白衍生的V区和T细胞受体衍生的C区组成的嵌合受体的表达。
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Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.对患有恶性黑色素瘤的人类体内针对自体肿瘤的特异性细胞溶解免疫反应的鉴定。
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用由抗体可变区和Fc受体γ链组成的嵌合基因重定向的人淋巴细胞对卵巢癌细胞进行裂解。

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

作者信息

Hwu P, Shafer G E, Treisman J, Schindler D G, Gross G, Cowherd R, Rosenberg S A, Eshhar Z

机构信息

Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

J Exp Med. 1993 Jul 1;178(1):361-6. doi: 10.1084/jem.178.1.361.

DOI:10.1084/jem.178.1.361
PMID:8315392
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2191075/
Abstract

To expand the spectrum of recognition of effector lymphocytes and to redirect them towards predefined targets, we have altered the specificity of human tumor-infiltrating lymphocytes (TIL) through stable modification with chimeric receptor genes consisting of single-chain antibody variable regions linked to the gamma subunit common to the immunoglobulin (Ig)G and IgE Fc receptors. Using either hapten or ovarian carcinoma-specific monoclonal antibodies, we constructed chimeric receptor genes and retrovirally introduced them into CD8+ TIL. Redirected TIL specifically lysed trinitrophenyl-labeled Daudi or a human ovarian carcinoma cell line (IGROV-1), and secreted granulocyte/macrophage colony-stimulating factor upon stimulation with the appropriate antigen. This strategy may allow new approaches towards the adoptive immunotherapy of cancer in humans.

摘要

为了扩大效应淋巴细胞的识别谱并将它们重定向至预定义的靶标，我们通过用嵌合受体基因进行稳定修饰改变了人肿瘤浸润淋巴细胞（TIL）的特异性，该嵌合受体基因由与免疫球蛋白（Ig）G和IgE Fc受体共有的γ亚基相连的单链抗体可变区组成。利用半抗原或卵巢癌特异性单克隆抗体，我们构建了嵌合受体基因，并通过逆转录病毒将其导入CD8 + TIL。重定向的TIL特异性裂解三硝基苯基标记的Daudi或人卵巢癌细胞系（IGROV-1），并在受到适当抗原刺激时分泌粒细胞/巨噬细胞集落刺激因子。该策略可能为人类癌症的过继性免疫治疗带来新方法。