Tomiyama S, Nonaka M, Yagi T
Department of Otolaryngology, Nippon Medical School, Tokyo.
Nihon Jibiinkoka Gakkai Kaiho. 1993 May;96(5):745-50. doi: 10.3950/jibiinkoka.96.745.
This study demonstrates that degeneration of vestibular sensory cells depends on the integrity of immune responses in the endolymphatic sac (ES). Degeneration of the saccule occurred nearly twice as often as degeneration of the utricle and ampulla. Perilymph antibody levels were assessed following direct antigen (KLH) challenge to the endolymphatic sac in systemic presensitized guinea pigs. Mean perilymph antibody levels were significantly elevated in ears showing degeneration as compared to those which did not. Serum anti-KLH antibody levels were also significantly elevated in the ears with degeneration as compared to those without. Whether degeneration or recovery occurs, is largely dependent on the level of systemic immunization and perilymph antibody level within one week of antigen challenge to the ES.
本研究表明，前庭感觉细胞的退化取决于内淋巴囊（ES）免疫反应的完整性。球囊的退化发生率几乎是椭圆囊和壶腹退化发生率的两倍。在全身预致敏的豚鼠中，向内淋巴囊直接注射抗原（KLH）后评估外淋巴抗体水平。与未出现退化的耳朵相比，出现退化的耳朵中外淋巴抗体平均水平显著升高。与未退化的耳朵相比，出现退化的耳朵中血清抗KLH抗体水平也显著升高。退化或恢复的发生在很大程度上取决于全身免疫水平以及向内淋巴囊抗原攻击后一周内外淋巴抗体水平。
