Granot E, Goodman-Weill M, Pizov G, Sherman Y
Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
J Pediatr Gastroenterol Nutr. 1993 May;16(4):397-401. doi: 10.1097/00005176-199305000-00009.
Small intestinal biopsies are part of the routine evaluation of children with chronic diarrhea and malabsorption, and are commonly performed via suction capsule. Because this technique entails x-ray exposure, longer procedure time, and technical failures, most small intestinal biopsies in adults are currently obtained via endoscopy. Endoscopy is believed to yield morphologically inferior specimens, and, therefore, its use for obtaining small intestinal biopsies in children has remained limited. The histological adequacy of biopsy specimens obtained in 30 children by endoscopy and in 30 children by suction capsule was compared. Biopsies were assessed for quality of orientation, size (length and depth), presence of Brunner's glands and crush artifact, and for the ability to confirm or exclude a mucosal abnormality. Small intestinal biopsies obtained via endoscopy were shown to yield tissue specimens that are histologically comparable to those obtained by suction capsule, and that are equally suitable for interpretation.
小肠活检是慢性腹泻和吸收不良儿童常规评估的一部分，通常通过抽吸胶囊进行。由于该技术需要接受X射线照射、操作时间较长且存在技术故障，目前大多数成人小肠活检是通过内镜检查获取的。人们认为内镜检查获得的标本形态较差，因此，其在儿童小肠活检中的应用仍然有限。比较了通过内镜检查在30名儿童中获得的活检标本与通过抽吸胶囊在30名儿童中获得的活检标本的组织学充分性。对活检标本的定向质量、大小（长度和深度）、布伦纳腺的存在情况和挤压假象以及确认或排除黏膜异常的能力进行了评估。结果显示，通过内镜检查获得的小肠活检组织标本在组织学上与通过抽吸胶囊获得的标本相当，同样适合进行解读。
