Sone Y, Kawano F, Nishimura Y, Kurisaki H, Tsukamoto A, Kiyokawa T, Sanada I, Shido T
Department of Internal Medicine, Kumamoto National Hospital.
Rinsho Ketsueki. 1993 May;34(5):670-2.
A 45-year-old woman with Bence-Jones type multiple myeloma was treated with natural type alpha-interferon (Namalwa interferon), 3 million IU every other day subcutaneously. After about 5 months, she developed hemolytic anemia. However, screening tests for autoantibodies, including direct and indirect antiglobulin (Coombs' tests), were negative. This report is the first case in which hemolytic anemia appeared to be caused by natural type alpha-interferon. It is likely that interferons will be used in treating increasing numbers of patients and that more patients will develop this complication.
一名45岁的本-周蛋白型多发性骨髓瘤女性患者接受了天然型α干扰素（纳马夸干扰素）治疗，每隔一天皮下注射300万国际单位。大约5个月后，她出现了溶血性贫血。然而，包括直接和间接抗球蛋白（库姆斯试验）在内的自身抗体筛查试验均为阴性。本报告是首例溶血性贫血似乎由天然型α干扰素引起的病例。随着越来越多的患者可能接受干扰素治疗，预计会有更多患者出现这种并发症。
