Hattori A, Orimo H
Department of Geriatrics, Tokyo University.
Nihon Ronen Igakkai Zasshi. 1993 Apr;30(4):260-5. doi: 10.3143/geriatrics.30.260.
In order to define the diagnostic criteria for diabetes mellitus in the elderly and to clarify how to manage the elderly diabetic patients, we examined risk factors for the development of diabetic retinopathy or ischemic heart disease in diabetics over 60 years old. Among 381 elderly diabetics, there were 127 patients with retinopathy at the first visit. Univariate analysis showed that the initial fasting plasma glucose (FPG) levels and the estimated duration of diabetes of patients with diabetic retinopathy were significantly higher than those of patients without diabetic retinopathy. The author studied 179 patients who were free of diabetic retinopathy on their first visit and were followed for at least 5 years in order to examine the relationships between the initial glucose levels and subsequent development of retinopathy. Eighty-one of the subjects developed diabetic retinopathy during follow-up period. The development of retinopathy was more common in patients with higher FPG (> 140 mg/dl), HbA1 (> 9%) or 2-h postload plasma glucose levels (> 280 mg/dl). Not only the initial FPG but also the mean FPG levels during the follow-up period were higher in subjects who developed retinopathy. These results indicate that 140 mg/dl or more of fasting plasma glucose levels in an adequate criterion for diabetes mellitus in the elderly, as well as in young and middle age subjects. In elderly diabetic patients, not only diabetic retinopathy but also ischemic heart disease developed so frequently that the quality of life in those patients is often disturbed.(ABSTRACT TRUNCATED AT 250 WORDS)
为了明确老年糖尿病的诊断标准并阐明如何管理老年糖尿病患者,我们研究了60岁以上糖尿病患者发生糖尿病视网膜病变或缺血性心脏病的危险因素。在381例老年糖尿病患者中,初诊时有127例患有视网膜病变。单因素分析显示,糖尿病视网膜病变患者的初始空腹血糖(FPG)水平和估计糖尿病病程显著高于无糖尿病视网膜病变的患者。作者研究了179例初诊时无糖尿病视网膜病变且随访至少5年的患者,以探讨初始血糖水平与随后视网膜病变发生之间的关系。其中81例受试者在随访期间发生了糖尿病视网膜病变。视网膜病变在FPG较高(>140mg/dl)、糖化血红蛋白(HbA1)>9%或服糖后2小时血糖水平>280mg/dl的患者中更常见。发生视网膜病变的受试者不仅初始FPG较高,随访期间的平均FPG水平也较高。这些结果表明,140mg/dl或更高的空腹血糖水平是老年以及中青年糖尿病患者的一个适当诊断标准。在老年糖尿病患者中,不仅糖尿病视网膜病变而且缺血性心脏病都很常见,这些患者的生活质量常常受到影响。(摘要截选至250字)