Noda H, Sugiyama S, Yamaguchi M, Tatsumi S, Sano Y, Konishi S, Furutani A, Yoshimura M
Department of Legal Medicine, Kinki University School of Medicine, Osaka, Japan.
Nihon Hoigaku Zasshi. 1993 Apr;47(2):147-52.
As environmental pollution due to waste fluids and gases from factories using lead (Pb), as well as domestic waste materials, has become a matter for public concern, studies on the accumulated levels of Pb in man have become necessary for defining the degree of contamination in the ordinary population. For this purpose, Pb levels in tissues of 76 forensic cadavers were determined in order to investigate the age distribution of accumulated Pb, and 120 samples were used to clarify secular changes in Pb accumulation during the last decade in the general population. The age group showing the highest Pb level was 50-59 years, with mean Pb contents per unit wet weight of 0.262, 0.520, 0.427 and 4.479 micrograms/g for heart, liver, kidney and rib, respectively. Each of these organs in all age groups exhibited almost the same Pb levels, but babies less than one year old had levels close to those in adults. However, ribs in babies exhibited much lower Pb levels. The levels in each organ were lower in individuals over 60 years old. A distinct age-related increase in Pb levels was found only in ribs from age 0 year to 50-59 years. The Pb levels in the heart, liver, kidney and rib showed a decrease during the last 10 years from 0.188 +/- 0.073 to 0.006 +/- 0.003 micrograms/g, from 0.307 +/- 0.169 to 0.076 +/- 0.057 micrograms/g, from 0.287 +/- 0.145 to 0.021 +/- 0.011 micrograms/g and from 3.203 +/- 1.477 to 2.366 +/- 1.469 micrograms/g, respectively.
由于使用铅（Pb）的工厂排放的废液和废气以及生活垃圾造成的环境污染已成为公众关注的问题，因此有必要开展关于人体中铅累积水平的研究，以确定普通人群的污染程度。为此，测定了76具法医尸体组织中的铅含量，以研究铅累积的年龄分布，并使用120个样本阐明过去十年普通人群中铅累积的长期变化。铅含量最高的年龄组为50-59岁，心脏、肝脏、肾脏和肋骨单位湿重的平均铅含量分别为0.262、0.520、0.427和4.479微克/克。所有年龄组的这些器官中的铅含量几乎相同，但一岁以下婴儿的铅含量接近成年人。然而，婴儿肋骨中的铅含量要低得多。60岁以上个体各器官中的铅含量较低。仅在0岁至50-59岁的肋骨中发现铅含量有明显的年龄相关增加。在过去10年中，心脏、肝脏、肾脏和肋骨中的铅含量分别从0.188±0.073微克/克降至0.006±0.003微克/克，从0.307±0.169微克/克降至0.076±0.057微克/克，从0.287±0.145微克/克降至0.021±0.011微克/克，从3.203±1.477微克/克降至2.366±1.469微克/克。
