Lieverse R J, Jansen J B, Lamers C B
Department of Gastroenterology-Hepatology, University Hospital Leiden, Netherlands.
Neth J Med. 1993 Apr;42(3-4):146-52.
Peripheral signals from stomach and small intestine are believed to induce satiation. In experimental animals, satiation factors can be transfused pointing to the humoral nature of the signal. Cholecystokinin (CCK) may be an important mediator, since infusion of exogenous CCK has been demonstrated to induce satiation and to inhibit gastric emptying. However, whether this effect of CCK is a physiological or pharmacological event is a matter of controversy. The significance of exogenous CCK or stimulation of endogenous CCK in the possible treatment of obesity requires further study.
来自胃和小肠的外周信号被认为可诱导饱腹感。在实验动物中，饱腹感因子可以通过输注来证实信号的体液性质。胆囊收缩素（CCK）可能是一种重要的介质，因为已证明输注外源性CCK可诱导饱腹感并抑制胃排空。然而，CCK的这种作用是生理事件还是药理事件仍存在争议。外源性CCK或刺激内源性CCK在肥胖症可能治疗中的意义需要进一步研究。
