de Jong A W, Hart W, Terburg M, Molenaar J L, Herbrink P, Hop W C
Department of Rehabilitation, Reinier de Graaf Gasthuis, Delft, Netherlands.
Neth J Med. 1993 Apr;42(3-4):93-8.
To determine whether young patients who suffered a stroke in the past, have a higher prevalence of ACA of LAC as compared to healthy controls, we evaluated 44 stroke patients and 46 controls in a case-control study for the presence of ACA and LAC. All the patients had had a stroke under the age of 50 yr and the stroke date was less than 5 yr ago (mean 2.5 yr). Stroke was defined as an ischaemic cerebral infarction and was confirmed by angiography, CT-scan or MRI. An age- and sex-matched group of healthy volunteers served as controls. The mean age of the patients was 41.4 yr (range 22-52 yr), and of the controls 36.8 yr (range 24-50 yr). Serum and plasma from both groups was examined for IgM- and IgG-ACA and LAC. One patient was positive for both IgG- and IgM-ACA, whereas 3 controls were found positive for IgG-ACA. For 2 patients and 5 controls an equivocal result was obtained for IgG-ACA or IgM-ACA. None of the patients or controls were positive for LAC. The differences between the patient and control group were statistically not significant. In conclusion, no difference was found in the prevalence of cardiolipin antibodies in sera from patients with a stroke within the last 5 yr and an age- and sex-matched control group. There was no correlation either between the presence of lupus anticoagulant and the occurrence of a stroke in the past.
为了确定既往有中风病史的年轻患者与健康对照相比，抗心磷脂抗体（ACA）或狼疮抗凝物（LAC）的患病率是否更高，我们在一项病例对照研究中评估了44例中风患者和46例对照，以检测ACA和LAC的存在情况。所有患者在50岁之前发生过中风，且中风时间在5年以内（平均2.5年）。中风定义为缺血性脑梗死，并通过血管造影、CT扫描或MRI确诊。一组年龄和性别匹配的健康志愿者作为对照。患者的平均年龄为41.4岁（范围22 - 52岁），对照的平均年龄为36.8岁（范围24 - 50岁）。检测两组的血清和血浆中的IgM-ACA、IgG-ACA以及LAC。1例患者IgG-ACA和IgM-ACA均呈阳性，而3例对照IgG-ACA呈阳性。2例患者和5例对照的IgG-ACA或IgM-ACA结果不明确。患者和对照中均无LAC呈阳性者。患者组和对照组之间的差异无统计学意义。总之，在过去5年内发生中风的患者与年龄和性别匹配的对照组血清中，心磷脂抗体的患病率无差异。狼疮抗凝物的存在与既往中风的发生之间也无相关性。
