通过细胞核DNA流式细胞术显示的中央核肌病的异质性。

Heterogeneity of centronuclear myopathy shown by flow cytometry of nuclear DNA.

作者信息

Metze K, Schnabel R, Mellin W, Gullotta F, Hiddemann W

机构信息

Institute of Neuropathology Bethel, Bielefeld, Germany.

出版信息

Neuropathol Appl Neurobiol. 1993 Apr;19(2):182-4. doi: 10.1111/j.1365-2990.1993.tb00425.x.

DOI:10.1111/j.1365-2990.1993.tb00425.x

PMID:8316338

Abstract

Determination of nuclear DNA by flow cytometry of skeletal muscle biopsies of three unrelated male patients with centronuclear (myotubular) myopathy demonstrated, in two patients, a normal pattern and, in one case, a near haploid DNA content in c. 60% of all nuclei, indicating muscle tissue mosaicism.

摘要

通过流式细胞术对三名无关的患有中央核（肌管）肌病的男性患者的骨骼肌活检组织进行核DNA测定，结果显示，两名患者的模式正常，而在一名患者中，约60%的细胞核中DNA含量接近单倍体，表明存在肌肉组织嵌合现象。