Papagelopoulos P J, Giannarakos D G, Lyritis G P
Mayo Medical School, Rochester, Minnesota.
Orthop Rev. 1993 May;22(5):585-93.
A distal femoral osteotomy in 46 rabbits was fixed either with biodegradable polydioxanone (PDS) thread and pins (group A, 31 animals) or with metallic Kirschner wire and pins (group B, 15 animals). Postoperatively, the distal part of each femur was removed and evaluated, and bone sections were evaluated by histology and histomorphometry. Macroscopic studies showed complete PDS absorption in all cases 24 weeks postoperatively. The histologic studies revealed new bone surrounding the area of the implant 3 weeks postoperatively, and at 24 weeks postoperatively, there was thinning or disappearance of the new bone around the implant. On the basis of the present study, PDS thread and pins show promise for the fixation of osteotomies or fractures of cancellous metaphyses of small long bones, such as metacarpals and phalanges.
对46只兔子进行股骨远端截骨术，分别采用可生物降解的聚二氧六环酮（PDS）线和钢针固定（A组，31只动物）或金属克氏针和钢针固定（B组，15只动物）。术后，切除每只股骨的远端部分并进行评估，骨切片通过组织学和组织形态计量学进行评估。宏观研究显示，术后24周时所有病例中的PDS均完全吸收。组织学研究显示，术后3周时植入物周围有新骨形成，术后24周时植入物周围的新骨变薄或消失。基于本研究，PDS线和钢针在固定小长骨松质骨干骺端截骨术或骨折（如掌骨和指骨）方面显示出应用前景。
