Graham C A, Sherwin B B
MRC Reproductive Biology Unit, Royal Edinburgh Hospital, Scotland.
Psychoneuroendocrinology. 1993;18(4):273-81. doi: 10.1016/0306-4530(93)90024-f.
This study investigated the effects of a triphasic oral contraceptive (OC) on mood and on sexual interest in a group of 45 women with premenstrual complaints. Subjects made daily ratings of mood and sexual interest for one baseline cycle and were then randomly assigned to receive either placebo or OC for 3 mo. Women who received the OC reported decreased sexual interest during the menstrual and postmenstrual phases of the cycle. The predominant effect of both the OC and the placebo on mood was one of improvement, particularly during the premenstrual phase. There was little evidence of co-variation of mood and sexual interest in either group. Although the mechanism for the adverse effects of the OC on levels of sexual interest in unknown, it is clear that this effect was not simply a consequence of pill-induced negative mood change. The findings provide evidence that mood and sexual desire are dissociable and suggest that OCs can have direct effects on women's sexuality.
本研究调查了一种三相口服避孕药（OC）对一组45名有经前不适症状女性的情绪及性兴趣的影响。受试者在一个基线周期内每天对情绪和性兴趣进行评分，然后随机分为两组，一组服用安慰剂，另一组服用OC，为期3个月。服用OC的女性报告称，在月经周期的月经期和月经后期性兴趣下降。OC和安慰剂对情绪的主要影响都是改善情绪，尤其是在经前期。两组中情绪和性兴趣几乎没有协变的证据。虽然OC对性兴趣水平产生不良影响的机制尚不清楚，但很明显，这种影响并非仅仅是药物引起的负面情绪变化的结果。这些发现提供了证据，表明情绪和性欲是可分离的，并表明OC可能对女性的性行为有直接影响。
