Singh P P, Kiran R
Department of Biochemistry, R.N.T. Medical College, Udaipur, Rajasthan, India.
Scanning Microsc. 1993 Mar;7(1):443-6.
Serum retinol levels were studied in: (a) 95, 56 and 43 normal subjects belonging to lower, middle and upper socio-economic groups respectively, (b) 35 adult males suffering from night blindness, (c) 27 subjects with low retinol levels, (d) 8 retinol deficient subjects (e) 17 male infants suffering from overt retinol deficiency, (f) 43 radiologically confirmed stone patients and (g) age and sex matched controls (infants 20; adults 120). The subjects included in groups b to f were clinically and radiologically examined for stone disease. Some inhibitors and promotors of stone disease were estimated in urine in groups b to g. It was found that 68% of subjects in lower socioeconomic group had serum retinol levels between 10 and 19 ug%, and 4% below 10 ug%, but none of them showed any symptoms of retinol deficiency. The subjects included in groups b to e did not show any significant difference in their urine chemistry although oxalate excretion was slightly but not significantly higher in comparison to controls. None of them showed radiological evidence of urinary stones. Thus, our results do not support an association between retinol deficiency and urolithiasis in the population studied.
(a) 分别属于社会经济地位较低、中等和较高群体的95名、56名和43名正常受试者；(b) 35名患有夜盲症的成年男性；(c) 27名视黄醇水平较低的受试者；(d) 8名视黄醇缺乏受试者；(e) 17名患有明显视黄醇缺乏的男婴；(f) 43名经放射学确诊的结石患者；(g) 年龄和性别匹配的对照组（婴儿20名；成年人120名）。对b至f组的受试者进行了结石病的临床和放射学检查。对b至g组的尿液中的一些结石病抑制剂和促进剂进行了测定。结果发现，社会经济地位较低群体中68%的受试者血清视黄醇水平在10至19微克%之间，4%低于10微克%，但他们均未表现出任何视黄醇缺乏的症状。b至e组的受试者尿液化学指标没有任何显著差异，尽管与对照组相比，草酸盐排泄略有升高，但不显著。他们均未表现出尿路结石的放射学证据。因此，我们的结果不支持在所研究人群中视黄醇缺乏与尿石症之间存在关联。
