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[对癌症患者口腔黏膜微核进行分析以评估化学制剂的致断裂效应]

[An analysis of the micronuclei in the oral mucosa of cancer patients for assessing the clastogenic effect of chemical preparations].

作者信息

Nersesian A K, Zil'fian V N, Kumkumadzhian V A, Nersesian A K

出版信息

Tsitol Genet. 1993 Jan-Feb;27(1):77-80.

PMID:8316958
Abstract

The frequency of micronuclei in the buccal mucosa cells have been investigated in healthy persons (donors) and patients with tumors before and after chemotherapy. It has been shown that frequency of micronuclei in the cells of patients before therapy and donors were at the same level. One day after chemotherapy the frequency of micronuclei was elevated 3.2 times.

摘要

已对健康人（捐赠者）以及肿瘤患者化疗前后颊黏膜细胞中的微核频率进行了研究。结果表明，治疗前患者细胞和捐赠者细胞中的微核频率处于同一水平。化疗一天后，微核频率升高了3.2倍。

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Tsitol Genet. 1993 Jan-Feb;27(1):77-80.
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Comments on the paper by E. M. Minicucci et al. "DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy".
Clin Exp Med. 2009 Mar;9(1):77-8; author reply 79-80. doi: 10.1007/s10238-008-0018-9. Epub 2008 Nov 7.