阿魏酸对7,12-二甲基苯并(a)蒽（DMBA）诱导的遗传毒性的抗诱变作用。
Antigenotoxic effect of ferulic acid in 7,12-dimethyl benz(a)-anthracene (DMBA) induced genotoxicity.
作者信息
Balakrishnan Subramanian, Menon Venugopal P, Manoharan Shanmugam, Rajalingam Kasinathan
机构信息
Department of Biochemistry & Biotechnology, Faculty of Science, Annamalai University, Annamalainagar-608002, Tamil Nadu, India.
出版信息
Afr J Tradit Complement Altern Med. 2007 Oct 27;5(1):32-8. doi: 10.4314/ajtcam.v5i1.31253.
The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30 mg kg(-1) b.w.). Pretreatment of ferulic acid orally at a dose of 40 mg kg(-1) b.w. for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster's bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced genotoxicity in golden Syrian hamsters.
通过评估细胞遗传学标记物、微核频率和染色体畸变，在7,12-二甲基苯并(a)蒽（DMBA）诱导的遗传毒性实验中，研究了阿魏酸对仓鼠骨髓的抗遗传毒性作用。通过腹腔单次注射DMBA（30 mg kg(-1)体重）诱导实验仓鼠产生遗传毒性。以40 mg kg(-1)体重的剂量口服阿魏酸预处理五天，可显著降低仓鼠骨髓中微核多染红细胞（MnPCEs）的频率和染色体畸变的百分比。因此，我们的结果表明，阿魏酸对DMBA诱导的金黄叙利亚仓鼠遗传毒性具有强大的抗遗传毒性作用。
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