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铅暴露工人的螯合疗法。

Chelation therapy in workers with lead exposure.

作者信息

Royce S, Rosenberg J

机构信息

Hazard Evaluation System and Information Service, California Department of Health Services, Berkeley 94704.

出版信息

West J Med. 1993 Apr;158(4):372-5.

PMID:8317123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1022063/
Abstract

Occupational lead overexposure remains a major problem. To evaluate the settings in which physicians appropriately prescribe chelation therapy for lead exposure, 7 cases were identified from physician phone calls and mandatory laboratory reporting of elevated blood lead levels to the California Department of Health Services. In the 2 workers with the highest blood lead levels (both of whom had severe symptoms), treatment was indicated. Physicians inappropriately prescribed chelating agents to workers with ongoing lead exposure as prophylaxis against rising blood lead levels and to treat atherosclerotic heart disease. Workers' personal physicians identified lead overexposure in 5 of the 7 cases. Workplace lead medical surveillance programs mandated by the federal Occupational Safety and Health Administration were inadequate in all 5 of the workplaces where information was available.

摘要

职业性铅过度暴露仍然是一个主要问题。为评估医生针对铅暴露合理开具螯合疗法的情况,从医生电话记录以及向加利福尼亚州卫生服务部强制报告的血铅水平升高情况中识别出7例病例。在血铅水平最高的2名工人(两人均有严重症状)中,需要进行治疗。医生不恰当地给仍在接触铅的工人开具螯合剂,作为预防血铅水平升高以及治疗动脉粥样硬化性心脏病的措施。7例病例中有5例是工人的私人医生发现铅过度暴露的。在所有可获取信息的5个工作场所中,联邦职业安全与健康管理局规定的工作场所铅医疗监测项目均不完善。

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本文引用的文献

1
Elimination kinetics of blood lead in workers with chronic lead intoxication.慢性铅中毒工人血铅的消除动力学
Am J Ind Med. 1985;8(1):33-42. doi: 10.1002/ajim.4700080105.
2
Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy.在乙二胺四乙酸二钠钙螯合治疗过程中铅的动员与再分布
J Pharmacol Exp Ther. 1987 Dec;243(3):804-13.
3
Mobilization of lead by calcium disodium edetate. A reappraisal.依地酸二钠钙对铅的动员作用。重新评估。
Am J Dis Child. 1987 Dec;141(12):1256-7. doi: 10.1001/archpedi.1987.04460120018020.
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2,3-Dimercaptosuccinic acid as an antidote for lead intoxication.
Clin Pharmacol Ther. 1985 Apr;37(4):431-8. doi: 10.1038/clpt.1985.67.
5
The lead-exposed worker.铅暴露工人。
JAMA. 1989 Jul 28;262(4):532-4.
6
Environmental and biological monitoring for lead exposure in California workplaces.加利福尼亚州工作场所铅暴露的环境与生物监测
Am J Public Health. 1990 Aug;80(8):921-5. doi: 10.2105/ajph.80.8.921.
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Chelation therapy.螯合疗法。
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8
Chelation therapy in workers exposed to lead. A critical review.
JAMA. 1976 Jun 28;235(26):2823-4.
9
Prophylactic chelation therapy in occupational lead poisoning: a review.职业性铅中毒的预防性螯合疗法:综述
Am Ind Hyg Assoc J. 1977 Oct;38(10):536-42. doi: 10.1080/0002889778507667.
10
Prevalence of lead disease among secondary lead smelter workers and biological indicators of lead exposure.
Environ Res. 1977 Oct;14(2):255-85. doi: 10.1016/0013-9351(77)90037-8.