Wilder R L
Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Agents Actions Suppl. 1993;41:3-9.
Hypothalamic secretion of corticotropin releasing hormone (CRH) triggers the secretion of pituitary ACTH and antiinflammatory adrenal corticosteroids. CRH is also secreted in local inflammatory sites such as the arthritic joint, but its action appears to be proinflammatory. This review notes the complex interrelationships of the nervous, endocrine, immune and inflammatory systems and suggests that abnormalities in these interactions may play a role in susceptibility to rheumatoid arthritis and various animal models of autoimmune diseases.
下丘脑分泌的促肾上腺皮质激素释放激素（CRH）会触发垂体促肾上腺皮质激素（ACTH）以及抗炎性肾上腺皮质类固醇的分泌。CRH也会在局部炎症部位分泌，如关节炎关节，但它的作用似乎是促炎性的。这篇综述指出了神经、内分泌、免疫和炎症系统之间复杂的相互关系，并表明这些相互作用中的异常可能在类风湿关节炎以及各种自身免疫性疾病动物模型的易感性中发挥作用。
