• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

下丘脑-垂体-肾上腺轴的调节与失调。促肾上腺皮质激素释放激素视角

Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. The corticotropin-releasing hormone perspective.

作者信息

Chrousos G P

机构信息

Section on Pediatric Endocrinology, National Institute of Child Health and Human Development, Bethesda, Maryland.

出版信息

Endocrinol Metab Clin North Am. 1992 Dec;21(4):833-58.

PMID:1486878
Abstract

This article is an up-to-date review of the impact that the discovery of corticotropin-releasing hormone (CRH) has had on basic science and clinical medicine. It discusses hypothalamic CRH, placental CRH, immune CRH, and hypothalamic and immune CRH. Clinical studies in normal and disease states and synthesis and future directions also are presented.

摘要

本文是一篇关于促肾上腺皮质激素释放激素（CRH）的发现对基础科学和临床医学影响的最新综述。它讨论了下丘脑CRH、胎盘CRH、免疫CRH以及下丘脑和免疫CRH。还介绍了正常和疾病状态下的临床研究以及合成和未来方向。

相似文献

1
Regulation and dysregulation of the hypothalamic-pituitary-adrenal axis. The corticotropin-releasing hormone perspective.下丘脑-垂体-肾上腺轴的调节与失调。促肾上腺皮质激素释放激素视角
Endocrinol Metab Clin North Am. 1992 Dec;21(4):833-58.
2
Corticotropin releasing hormone and the hypothalamic-pituitary-adrenal axis in the regulation of inflammatory arthritis.促肾上腺皮质激素释放激素与下丘脑-垂体-肾上腺轴在炎性关节炎调节中的作用
Agents Actions Suppl. 1993;41:3-9.
3
Corticotropin releasing hormone: relevance to normal physiology and to the pathophysiology and differential diagnosis of hypercortisolism and adrenal insufficiency.促肾上腺皮质激素释放激素：与正常生理学、高皮质醇血症及肾上腺功能不全的病理生理学和鉴别诊断的相关性
Adv Biochem Psychopharmacol. 1987;43:183-200.
4
The hypothalamic-pituitary-adrenal and the hypothalamic- pituitary-gonadal axes interplay.下丘脑 - 垂体 - 肾上腺轴与下丘脑 - 垂体 - 性腺轴相互作用。
Pediatr Endocrinol Rev. 2006 Jan;3 Suppl 1:172-81.
5
Corticotropin-releasing hormone, stress and human reproduction: an update.促肾上腺皮质激素释放激素、应激与人类生殖：最新进展。
J Reprod Immunol. 2010 May;85(1):33-9. doi: 10.1016/j.jri.2010.02.005.
6
Hypothalamic-pituitary-adrenal axis and immune system.下丘脑-垂体-肾上腺轴与免疫系统。
Acta Neurol (Napoli). 1994 Aug;16(4):206-13.
7
The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease.促肾上腺皮质激素释放激素在免疫介导的皮肤炎症性疾病中的作用。
Exp Dermatol. 2006 Mar;15(3):143-53. doi: 10.1111/j.1600-0625.2006.00382.x.
8
Functions of corticotropin-releasing hormone in anthropoid primates: from brain to placenta.促肾上腺皮质激素释放激素在类人猿灵长类动物中的作用：从脑到胎盘。
Am J Hum Biol. 2006 Jul-Aug;18(4):431-47. doi: 10.1002/ajhb.20521.
9
The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved.促肾上腺皮质激素释放激素网络与下丘脑-垂体-肾上腺轴：相关的分子和细胞机制。
Neuroendocrinology. 2011;94(1):12-20. doi: 10.1159/000328226. Epub 2011 May 13.
10
CRH mRNA expression in the hypothalamic paraventricular nucleus is inhibited despite the activation of the hypothalamo-pituitary-adrenal axis during starvation.尽管饥饿期间下丘脑 - 垂体 - 肾上腺轴被激活，但下丘脑室旁核中的促肾上腺皮质激素释放激素（CRH）信使核糖核酸（mRNA）表达仍受到抑制。
Brain Res. 2008 Sep 4;1228:107-12. doi: 10.1016/j.brainres.2008.06.065. Epub 2008 Jun 26.

引用本文的文献

1
Amyotrophic lateral sclerosis (ALS) and the endocrine system: Are there any further ties to be explored?肌萎缩侧索硬化症（ALS）与内分泌系统：是否还有其他有待探索的联系？
Aging Brain. 2021 Nov 8;1:100024. doi: 10.1016/j.nbas.2021.100024. eCollection 2021.
2
The hypothalamic-pituitary-adrenal axis response to ovine corticotropin-releasing-hormone stimulation tests in healthy and hospitalized foals.健康和住院小马驹对羊促肾上腺皮质激素释放激素刺激试验的下丘脑-垂体-肾上腺轴反应。
J Vet Intern Med. 2023 Jan;37(1):292-301. doi: 10.1111/jvim.16604. Epub 2023 Jan 18.
3
Hippocampus-Anterior Hypothalamic Circuit Modulates Stress-Induced Endocrine and Behavioral Response.
海马-下丘脑前区回路调节应激诱导的内分泌和行为反应。
Front Neural Circuits. 2022 Jun 20;16:894722. doi: 10.3389/fncir.2022.894722. eCollection 2022.
4
High risk of drug toxicity in social isolation stress due to liver dysfunction: Role of oxidative stress and inflammation.社交隔离应激导致肝功能障碍时的药物毒性风险增加：氧化应激和炎症的作用。
Brain Behav. 2021 Aug;11(8):e2317. doi: 10.1002/brb3.2317. Epub 2021 Aug 1.
5
Elephant seal muscle cells adapt to sustained glucocorticoid exposure by shifting their metabolic phenotype.象海豹肌肉细胞通过改变其代谢表型来适应持续的糖皮质激素暴露。
Am J Physiol Regul Integr Comp Physiol. 2021 Sep 1;321(3):R413-R428. doi: 10.1152/ajpregu.00052.2021. Epub 2021 Jul 14.
6
Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders.糖皮质激素信号转导与应激相关障碍的表观遗传学改变。
Int J Mol Sci. 2021 May 31;22(11):5964. doi: 10.3390/ijms22115964.
7
The Putative Role of Thyroid Hormones and Vitamin D on Severity and Quality of Life in Psoriasis.甲状腺激素和维生素D在银屑病严重程度及生活质量方面的潜在作用
Int J Appl Basic Med Res. 2020 Jul-Sep;10(3):173-177. doi: 10.4103/ijabmr.IJABMR_437_19. Epub 2020 Jul 11.
8
Psychotropic medication use during pregnancy and gestational age at delivery.孕期使用精神药物与分娩时的胎龄。
Ann Epidemiol. 2021 Jan;53:34-41.e2. doi: 10.1016/j.annepidem.2020.08.010. Epub 2020 Aug 22.
9
Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress.压力与昼夜节律系统的多级相互作用：对创伤性应激的影响
Front Psychiatry. 2020 Jan 28;10:1003. doi: 10.3389/fpsyt.2019.01003. eCollection 2019.
10
Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis.探讨阴道微生物群的组成：营养和益生菌因素在维持阴道正常菌群中的作用。
Nutrients. 2020 Feb 6;12(2):419. doi: 10.3390/nu12020419.