Miyao M, Tazawa H, Motoyama M, Suzuki A, Ooishi M
Department of Ophthalmology, Niigata University School of Medicine, Niigata Cancer Center Hospital, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Mar;97(3):318-23.
We studied the intraocular penetration of 42 antibiotics in white rabbit eyes between 1980 to 1990 in our department. The parenteral route (intravenous, intramuscular): the ratios of maximum aqueous humor to serum level were 5.28-11.6% in penicillins (PCs), 5.95-20.17% in cephems and 13.4-30.27% in aminoglycosides (AGs). The aqueous concentration of antibiotics reached a peak within 1/4-1 hour after injection. Oral administration: the ratios of aqueous to serum level were 8.52-20.6% in PCs, 3.62-20.11% in cephems, 22.8-75.8% in macrolides (MLs) and 6.38-23.6% in quinolones. The aqueous concentration of antibiotics reached a peak within 1-4 hours after oral administration. The ratio of aqueous to serum level was the highest in MLs. The aqueous level reached a peak faster and the ratio of aqueous to serum level was higher by injection than by oral administration.
1980年至1990年期间，我们科室对白兔眼部42种抗生素的眼内渗透性进行了研究。肠胃外途径（静脉注射、肌肉注射）：青霉素类（PCs）药物房水与血清最高浓度之比为5.28 - 11.6%，头孢菌素类为5.95 - 20.17%，氨基糖苷类（AGs）为13.4 - 30.27%。注射后1/4 - 1小时内抗生素房水浓度达到峰值。口服给药：PCs药物房水与血清浓度之比为8.52 - 20.6%，头孢菌素类为3.62 - 20.11%，大环内酯类（MLs）为22.8 - 75.8%，喹诺酮类为6.38 - 23.6%。口服给药后1 - 4小时内抗生素房水浓度达到峰值。MLs药物房水与血清浓度之比最高。房水浓度达到峰值的速度更快，且注射给药时房水与血清浓度之比高于口服给药。
