Ito M
Department of Ophthalmology, School of Medicine, Kobe University, Japan.
Nippon Ganka Gakkai Zasshi. 1993 Mar;97(3):390-5.
The disc rim color changes in 40 eyes with primary open angle glaucoma (POAG) were studied using a computerized color analysis system. Optic disc color was evaluated by quantification of the red ratio based on the analyzed level of red, green, and blue elements. The correlation among the changes in neuroretinal rim color, visual field and cup area to disc area ratio (C/D.A) was evaluated. In 18 eyes in the early stage, with total initial loss less than 100 dB, the disc color change correlated with both mean sensitivity decrease (Pearson's r = 0.7410, p = 0.0004) and C/D. A increase (Pearson's r = 0.4698, p = 0.0492). In 22 eyes in the middle stage with total initial loss over 100 dB, the disc color variation correlated with mean sensitivity loss (Pearson's r = 0.7503, p < 0.0001) but not with C/D. A (Pearson's r = 0.2980, p = 0.1780). Neuroretinal rim color changes correlated with the value of mean sensitivity loss at any stage of POAG. These results suggest that neuroretinal rim color change in eyes at an early stage depend on a different histological change from that in the middle stage in POAG.
采用计算机化颜色分析系统，对40只原发性开角型青光眼（POAG）患者的视盘边缘颜色变化进行了研究。通过对红、绿、蓝三原色成分分析水平的量化，对视盘颜色进行评估。评估了神经视网膜边缘颜色变化、视野以及杯盘面积比（C/D.A）之间的相关性。在18只早期眼睛中，初始总损失小于100 dB，视盘颜色变化与平均敏感度下降（Pearson相关系数r = 0.7410，p = 0.0004）和C/D.A增加（Pearson相关系数r = 0.4698，p = 0.0492）均相关。在22只中期眼睛中，初始总损失超过100 dB，视盘颜色变化与平均敏感度损失（Pearson相关系数r = 0.7503，p < 0.0001）相关，但与C/D.A无关（Pearson相关系数r = 0.2980，p = 0.1780）。在POAG的任何阶段，神经视网膜边缘颜色变化均与平均敏感度损失值相关。这些结果表明，POAG早期眼睛的神经视网膜边缘颜色变化所依赖的组织学变化与中期不同。
