Deal S E, Pandak W M, Heuman D M
Medical College of Virginia, McGuire Veterans Affairs Medical Center, Division of Gastroenterology, Richmond.
Am J Gastroenterol. 1993 Jul;88(7):1050-3.
Ketorolac tromethamine (KT) is a new non-narcotic parenteral analgesic which lacks the respiratory depressant and hypotensive side effects of narcotics. Our aim was to determine whether KT can reduce requirements for narcotics and narcotic side effects in colonoscopy. In a randomized, double-blind trial, either intravenous KT (n = 30) or placebo (n = 30) was administered as a preprocedure analgesic to male patients undergoing colonoscopy. Patients who had pain during colonoscopy received supplemental diazepam and meperidine as required to maintain comfort. KT treatment did not affect patient comfort. No significant difference in the dose of diazepam or meperidine required was noted between the study and the placebo group, and there was no difference in the number of patients who required supplemental narcotics. The incidences of hypotension or arterial oxygen desaturation were similar in the KT- and placebo-treated patients. Ten patients in the KT group and four patients in the placebo group reported discomfort at the site of injection. We conclude that intravenous ketorolac tromethamine is no better than placebo as an analgesic premedication in colonoscopy.
酮咯酸氨丁三醇（KT）是一种新型非麻醉性注射用镇痛药，无麻醉药所致的呼吸抑制及降压副作用。我们的目的是确定KT是否能减少结肠镜检查时麻醉药的用量及麻醉药副作用。在一项随机双盲试验中，对接受结肠镜检查的男性患者，术前分别静脉注射KT（n = 30）或安慰剂（n = 30）作为镇痛剂。结肠镜检查时疼痛的患者根据需要额外给予地西泮和哌替啶以保持舒适。KT治疗不影响患者舒适度。研究组和安慰剂组在所需地西泮或哌替啶剂量上无显著差异，需要额外麻醉药的患者数量也无差异。KT治疗组和安慰剂治疗组患者低血压或动脉血氧饱和度降低的发生率相似。KT组有10例患者和安慰剂组有4例患者报告注射部位不适。我们得出结论，在结肠镜检查中，静脉注射酮咯酸氨丁三醇作为镇痛术前用药并不比安慰剂更好。
