Campbell D N, Lim M, Muir M K, O'Sullivan G, Falcon M, Fison P, Woods R
St Thomas' Hospital, London.
Anaesthesia. 1993 May;48(5):422-8. doi: 10.1111/j.1365-2044.1993.tb07019.x.
One hundred and sixty-nine patients (aged 65-98 years) were randomised to receive either local or general anaesthesia for cataract surgery. Cognitive function was assessed using a battery of psychometric tests performed pre-operatively, and at 24 h, 2 weeks and 3 months postoperatively. Oxygen saturation, blood pressure and heart rate were monitored and the results recorded throughout the anaesthetic and immediate recovery period. In the general anaesthetic group, 19% of patients experienced at least one episode of oxygen desaturation during the procedure compared with none in the local anaesthetic group. Pulse rate and blood pressure were stable in the local anaesthetic group compared with the general anaesthetic group where marked fluctuations were noted; 61% of patients in the general anaesthetic group experienced falls in systolic blood pressure greater than 30% of the pre-induction value. No evidence of long-term postoperative cognitive dysfunction was detected and there was no significant difference between the performances of the two groups.
169名年龄在65至98岁之间的患者被随机分配接受白内障手术的局部麻醉或全身麻醉。术前、术后24小时、2周和3个月使用一系列心理测量测试评估认知功能。在整个麻醉和即时恢复期间监测血氧饱和度、血压和心率并记录结果。全身麻醉组中,19%的患者在手术过程中至少经历了一次氧饱和度下降,而局部麻醉组中无此情况。与全身麻醉组中出现明显波动相比,局部麻醉组的脉搏率和血压稳定;全身麻醉组中61%的患者收缩压下降超过诱导前值的30%。未检测到长期术后认知功能障碍的证据,两组表现之间无显著差异。