维甲酸信号转导通路。

Retinoic acid signal transduction pathways.

作者信息

Leid M, Kastner P, Durand B, Krust A, Leroy P, Lyons R, Mendelsohn C, Nagpal S, Nakshatri H, Reibel C

机构信息

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS U/184 de Biologie Moléculaire et de Génie Génétique de I'INSERM, Institut de Chimie Biologique-Faculté de Médecine, Strasbourg, France.

出版信息

Ann N Y Acad Sci. 1993 Jun 11;684:19-34. doi: 10.1111/j.1749-6632.1993.tb32268.x.

DOI:10.1111/j.1749-6632.1993.tb32268.x

PMID:8317828

Abstract

Complexity in the retinoid signaling system arises from a combination of several forms of retinoic acid which possess differential activities, multiple cytoplasmic binding proteins and nuclear receptors that have distinct ligand specificities and functional properties, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric interactions between the two classes of nuclear retinoic acid receptors and between retinoic acid receptors and some other members of the nuclear receptor superfamily. Thus, a complex array of combinatorial effects is beginning to emerge that may account for the pleiotropic effects of retinoids.

摘要

维甲酸信号系统的复杂性源于多种具有不同活性的维甲酸形式、多种具有不同配体特异性和功能特性的细胞质结合蛋白及核受体，以及多态性维甲酸反应元件的存在。两类核维甲酸受体之间以及维甲酸受体与核受体超家族的其他一些成员之间的异二聚体相互作用似乎还产生了额外的多样性。因此，一系列复杂的组合效应开始显现，这可能解释了维甲酸的多效性作用。