Lartigau E, Eschwege F, Lusinchi A, Wibault P, Luboinski B
Département de Radiothérapie, Institut Gustave-roussy, Villejuif.
Ann Otolaryngol Chir Cervicofac. 1993;110(1):42-5.
Tumors of the tonsillar Fossa classed T1T2 are generally treated by irradiation with high rates of local control. Patient survival is related to the risk of developing distant metastatic disease and second head and neck cancers. The use of induction chemotherapy for squamous cell carcinoma of the head and neck gives a high rate of clinical tumor response and for this reason, it is increasingly used in standard treatment regimens. However, the long term results in terms of improved local control and improved survival (from a decreased rate of metastases) has not been clearly demonstrated. In addition, the toxicity of primary chemotherapy is not negligible. After review of the literature, the role of induction chemotherapy should be evaluated only in reference to randomized trials.
扁桃体窝T1T2级肿瘤一般采用放疗治疗，局部控制率较高。患者的生存率与发生远处转移性疾病及第二原发性头颈癌的风险相关。对头颈部鳞状细胞癌使用诱导化疗可获得较高的临床肿瘤缓解率，因此，它在标准治疗方案中的应用越来越多。然而，在改善局部控制和提高生存率（通过降低转移率）方面的长期效果尚未得到明确证实。此外，初始化疗的毒性也不容忽视。在查阅文献后，诱导化疗的作用应仅参考随机试验来评估。
