Yamanaka Y, Friess H, Kobrin M S, Buchler M, Beger H G, Korc M
Department of Medicine, University of California, Irvine 92717.
Anticancer Res. 1993 May-Jun;13(3):565-9.
Immunohistochemical analysis for the epidermal growth factor receptor (EGFR), EGF and transforming growth factor-alpha (TGF-alpha) was performed in 87 human pancreatic carcinomas. Expression frequencies for EGFR, EGF, and TGF-alpha were 43%, 46% and 54%, respectively. Coexpression of the receptor and at least one of its ligands occurred in 38% of the tumors, and correlated with large tumor size, advanced clinical staging, and decreased survival period. In situ hybridization revealed that the respective mRNAs were also overexpressed in the carcinomas. These findings suggest that coexpression of EGFR and its ligands may contribute to the aggressiveness of human pancreatic cancer.
对87例人类胰腺癌进行了表皮生长因子受体（EGFR）、表皮生长因子（EGF）和转化生长因子-α（TGF-α）的免疫组织化学分析。EGFR、EGF和TGF-α的表达频率分别为43%、46%和54%。受体与其至少一种配体的共表达在38%的肿瘤中出现，并且与肿瘤体积大、临床分期晚和生存期缩短相关。原位杂交显示相应的mRNA在癌组织中也过度表达。这些发现提示EGFR及其配体的共表达可能促使人类胰腺癌具有侵袭性。
