Schleuning M, Brumme V, Wilmanns W
Department of Internal Medicine III, Klinikum Grosshadern, University of Munich, Germany.
Anticancer Res. 1993 May-Jun;13(3):599-602.
The effect of the phenothiazine derivative fluphenazine has been studied in the human leukemic T-cell line H33-HJ JA1, which is an Interleukin-2 (IL-2) producing cell line derived from Jurkat cells. This cell line shows a highly proliferative activity in response to the autocrine produced IL-2. The phenothiazine fluphenazine (1-10 microM) inhibited this proliferation in a dose-dependent manner, as evidenced by the incorporation of (3H)-Thymidine. In analogy, growth inhibition by fluphenazine has been investigated in the human myeloblastic HL-60 cell line. The spontaneous growth of this cell line was also inhibited by fluphenazine at pharmacologically relevant micromolar concentrations. These results suggest that the use of phenothiazines might be helpful in antileukemic regimens.
已在人白血病T细胞系H33-HJ JA1中研究了吩噻嗪衍生物氟奋乃静的作用，该细胞系是一种源自Jurkat细胞的产生白细胞介素-2（IL-2）的细胞系。该细胞系对自分泌产生的IL-2表现出高度增殖活性。吩噻嗪氟奋乃静（1-10微摩尔）以剂量依赖方式抑制这种增殖，这通过（3H）-胸腺嘧啶核苷掺入得到证明。类似地，已在人髓母细胞HL-60细胞系中研究了氟奋乃静的生长抑制作用。该细胞系的自发生长在药理学相关的微摩尔浓度下也受到氟奋乃静的抑制。这些结果表明，使用吩噻嗪类药物可能有助于抗白血病治疗方案。
