Ahlers Caroline B, Hristovski Dimitar, Kilicoglu Halil, Rindflesch Thomas C
National Library of Medicine, Bethesda, MD, USA.
AMIA Annu Symp Proc. 2007 Oct 11;2007:6-10.
Drug therapies are often used effectively without their underlying mechanism being completely understood. We exploit the literature-based discovery paradigm to investigate these mechanisms and propose a discovery pattern that draws on semantic predications extracted from MEDLINE citations. The use of semantic predications and the discovery pattern provides a way to uncover previously unnoticed associations between pharmacologic and bioactive substances on the one hand and bioactive substances and disorders on the other. In this paper, we concentrate on research investigating the use of antipsychotic agents used for treatment of cancer. Our method resulted in five biomolecules that may provide a link between the antipsychotic agents and cancer: brain-derived neurotrophic factor, CYP2D6, glucocorticoid receptor, PRL, and TNF.
药物疗法常常能有效发挥作用，但其潜在机制却并未被完全理解。我们利用基于文献的发现范式来研究这些机制，并提出一种发现模式，该模式借鉴了从MEDLINE引用文献中提取的语义预测。语义预测和发现模式的使用提供了一种方法，一方面揭示药物和生物活性物质之间，另一方面揭示生物活性物质和疾病之间以前未被注意到的关联。在本文中，我们专注于研究用于治疗癌症的抗精神病药物的使用情况。我们的方法得出了五种生物分子，它们可能在抗精神病药物和癌症之间建立联系：脑源性神经营养因子、CYP2D6、糖皮质激素受体、催乳素和肿瘤坏死因子。
