Kadam P, Steele P, Li Y Q, Preisler H
University of Cincinnati Medical Center, Ohio.
Anticancer Res. 1993 May-Jun;13(3):747-51.
The "constitutive" expression of the c-myc gene was detected in leukemia cells obtained from 4 patients with an acute myeloid leukemia, 3 with chronic myeloid leukemia and 1 with a myelodysplastic syndrome. Studies were undertaken to determine whether or not the myc gene was rearranged or mutated in exon I within a 3'Pvu II region, a transcriptional attenuation site. Studies to explore the possibility of a point mutation in the N-ras gene were also conducted. No abnormalities were detected in either gene. Studies should be undertaken evaluating the possibility of a post-transcriptional mechanism, such as alteration of RNA stability, which could be responsible for the constitutive expression of c-myc gene.
在4例急性髓性白血病、3例慢性髓性白血病和1例骨髓增生异常综合征患者的白血病细胞中检测到c-myc基因的“组成型”表达。开展研究以确定myc基因在转录衰减位点3'Pvu II区域的外显子I中是否发生重排或突变。还进行了探索N-ras基因点突变可能性的研究。在这两个基因中均未检测到异常。应开展研究评估转录后机制的可能性，如RNA稳定性改变，其可能是c-myc基因组成型表达的原因。
