Moragas A, Castells C, Sans M
Department of Pathology, Ciutat Sanitaria Universitaria Vall d'Hebron, Barcelona, Spain.
Anal Quant Cytol Histol. 1993 Apr;15(2):75-82.
Fractographic techniques based on mathematical morphology were used to study aging-related epidermal changes in abdominal skin samples obtained from 96 autopsy cases. Three linear roughness indices were evaluated for the rete peg profile and the shrinkage effect on the basal layer and interface between the granular and horny layers. Elderly subjects had a 36.3% decrease in rete peg-related roughness index when compared with younger subjects. This roughness index has been corrected, with shrinkage due to skin elasticity taken into account. For females, fitting of a logistic decay function yielded a curve with right and left asymptotes and a steeper descent between 40 and 60 years. Half value time--i.e., the time when half rete peg profile flattening occurred--was 46.8 years. In contrast, males showed almost monotonical decay. Epidermal thickness measured between rete pegs showed the same exponential decline for both sexes, with values from 22.6 to 11.4 microns. Skin shrinkage in elderly subjects decreased 22% in superficial layers and only 6% in the lower epidermis. In both cases shrinkage had a linear relation with age, and no sex differences were found.
基于数学形态学的断口金相技术用于研究从96例尸检病例获取的腹部皮肤样本中与衰老相关的表皮变化。评估了三种线性粗糙度指数，用于评估 rete 钉突轮廓以及对基底层以及颗粒层与角质层之间界面的收缩效应。与年轻受试者相比，老年受试者的 rete 钉突相关粗糙度指数降低了36.3%。该粗糙度指数已进行校正，已考虑到皮肤弹性引起的收缩。对于女性，逻辑衰减函数拟合产生了一条具有左右渐近线且在40至60岁之间下降更陡峭的曲线。半衰期（即 rete 钉突轮廓扁平化发生一半时的时间）为46.8岁。相比之下，男性显示出几乎单调的衰减。在 rete 钉突之间测量的表皮厚度在两性中均呈现相同的指数下降，值从22.6微米降至11.4微米。老年受试者的皮肤收缩在表层降低了22%，而在表皮下层仅降低了6%。在这两种情况下，收缩与年龄呈线性关系，未发现性别差异。
