Reinhart D J, Latson T W, Whitten C W, Klein K W, Allison P M, Patel M
Department of Anesthesiology, University of Texas Southwestern Medical Center, Dallas.
J Clin Anesth. 1993 May-Jun;5(3):216-20. doi: 10.1016/0952-8180(93)90018-a.
To evaluate the effect of ketorolac tromethamine on coagulation using thromboelastography (TEG).
TEGs were performed in each patient before and after ketorolac administration. Each patient's predrug results were used as control measurements for comparison with the postdrug results.
Medical center surgical unit.
Twenty ASA physical status I and II patients undergoing minor elective surgery; 12 healthy volunteers.
TEGs were performed in all subjects before and 60 minutes after the intramuscular (IM) administration of ketorolac tromethamine 60 mg. Ten surgical patients were studied in the intraoperative period, and 10 surgical patients were studied in the postoperative period. The 12 healthy volunteers did not undergo a surgical procedure.
Specific parameters assessed from the TEGs were reaction time (R time), coagulation time (RK time), clot formation rate (angle of deflection), and maximum clot strength (maximum amplitude of deflection). Ketorolac administration did not cause statistically significant changes in these parameters in any of the three groups studied.
IM administration of ketorolac tromethamine 60 mg did not significantly alter the speed of formation or viscoelastic strength of clots as measured by TEG. These results provide additional support for prior clinical studies confirming the safety of ketorolac administration in the perioperative period.
使用血栓弹力图（TEG）评估酮咯酸氨丁三醇对凝血的影响。
在每位患者使用酮咯酸之前和之后进行TEG检测。每位患者用药前的结果用作对照测量值，以与用药后的结果进行比较。
医疗中心外科病房。
20例美国麻醉医师协会（ASA）身体状况为I级和II级的接受小型择期手术的患者；12名健康志愿者。
在所有受试者肌肉注射60毫克酮咯酸氨丁三醇之前和之后60分钟进行TEG检测。10例手术患者在术中期进行研究，10例手术患者在术后进行研究。12名健康志愿者未接受外科手术。
从TEG检测中评估的特定参数为反应时间（R时间）、凝血时间（RK时间）、血块形成率（偏转角度）和最大血块强度（最大偏转幅度）。在研究的三组中的任何一组中，使用酮咯酸均未导致这些参数出现统计学上的显著变化。
肌肉注射60毫克酮咯酸氨丁三醇不会显著改变通过TEG测量的血块形成速度或粘弹性强度。这些结果为先前的临床研究提供了额外支持，这些研究证实了围手术期使用酮咯酸的安全性。
